SL/Khは内在性レトロウィルスのプロウィルスの挿入による遺伝子の活性化によりリンパ腫を発生する．SL/Khの一部のリンパ腫はプロウィルスによりStat5aがさまざまな遺伝子を活性化し，かつ多くの因子と対応することによって，Pro-B細胞の腫瘍増殖によるものであることが明らかになっている．B細胞の初期分化過程とそのガン化を研究する上で有用なモデルマウスである． SL/Kh SL/Kh Sibling Mating High incidence of pre-B lymphomas at early age C (3-6 months) Sibling Mating 志佐　湍 Necessary documents for ordering:<ol><li>Order form (<A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_4.docx">Japanese</A> / <A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_b.docx">English</A>)</li><li>Category I MTA: MTA for distribution with RIKEN BRC (<A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_5.docx">Japanese</A> / <A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_c.docx">English</A>)</li></ol> 埼玉県立がんセンター研究所 SL系統はSwiss miceの交雑群に由来し，白血病高発系統として遺伝研の土川博士によって育成された．その後，九大で4つにサブライン化された．SL/Khはそのうちの一つ．その後，愛知県がんセンターを経て(+F35)，埼玉がんセンター(志佐博士)へ導入されたのち(+F54-55)，理研BRCへ導入された． SL系統はSwiss miceの交雑群に由来し，白血病高発系統として遺伝研の土川博士によって育成された．その後，九大で4つにサブライン化された．SL/Khはそのうちの一つ．その後，愛知県がんセンターを経て(+F35)，埼玉がんセンター(志佐博士)へ導入されたのち(+F54-55)，理研BRCへ導入された．白血病高発系統．連産性は低い．3カ月程度で精子が採取できなくなる．飼育過密が高いと癌を高発する傾向がある。 false 条件を付加しない。 C（3〜6か月） Research Institute for Clinical Oncology, Saitama Cancer Center SL/Kh is a member of the spontaneous leukemia family of mice, originated from outbred Swiss albino mice. Based on genotype analysis using microsatellite markers, SL/Kh was defined as a recombinant congenic strain between proto-SL and AKR strain mice. This strain develops pre-B lympomas by reintegration of the endogenous ecotropic MuLV provirus into a number of common integration sites, including Stat5a, Evi3, c-Myc, Stat5b, N-Myc, and others. SL/Kh is useful for an excellent multifactorial disease model. Cancer Research No specific terms and conditions. (The DEPOSITOR waives its own rights under any patents, intellectual property, or other proprietary rights with respect to the results to be obtained by use of the BIOLOGICAL RESOURCE.) RBRC00222 白血病高発系統．連産性は低い．3カ月程度で精子が採取できなくなる．飼育過密が高いと癌を高発する傾向がある。 Hayase SHISA The spontaneous leukemia (SL) strain was originated from outbred Swiss albino mice, developed as a high-leukemia strain by Dr. K. Tsuchikawa in Mishima. At least 4 substrains, namely SL/Am, SL/Kh, SL/Ni, and SL/QDj had been established and maintained. SL/Kh and SL/Ni strains were deposited by Dr. Hayase Shisa, Saitama Cancer Center Institute. Pregnant females were transferred to RIKEN Tsukuba Institute, their babies were cleaned up by caesarean section, and introduced into the SPF facility. The spontaneous leukemia (SL) strain was originated from outbred Swiss albino mice, developed as a high-leukemia strain by Dr. K. Tsuchikawa in Mishima. At least 4 substrains, namely SL/Am, SL/Kh, SL/Ni, and SL/QDj had been established and maintained. SL/Kh and SL/Ni strains were deposited by Dr. Hayase Shisa, Saitama Cancer Center Institute. Pregnant females were transferred to RIKEN Tsukuba Institute, their babies were cleaned up by caesarean section, and introduced into the SPF facility.High incidence of pre-B lymphomas at early age